ECOLOGY/EVOLUTION: Maintaining One's Niche

Niche Market Pricing and Strategies for Maintaining Price Premiums

Overview Developing products that not only add value but also increase profitability is the goal of virtually all niche food and agricultural product producers and manufacturers. Large-scale food product manufacturers often accomplish this goal through several strategies, including undertaking market research to identify relatively large segments of the market to serve as potential customers, e...

The Ones We Know and the Ones We Don’t

When you open your eyes in the morning, you usually see what you expect to see. Often it will be your bedroom, with things where you left them before you went to sleep. What if you opened your eyes and unexpectedly found yourself in a steaming tropical jungle? Why do we have expectations about what is about to happen to us? Why do we get surprised when something unexpected happens to us? More g...

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Optimization of Ex Vivo Expansion of Limbal Epithelial Progenitors by Maintaining Native Niche Cells on Denuded Amniotic Membrane.

PURPOSE Transplantation of ex vivo expanded limbal epithelial progenitor cells (LEPCs) on epithelially denuded amniotic membrane (dAM) in supplemented hormonal epithelial medium (SHEM) is an alternative solution for treating corneal blindness due to limbal stem cell (SC) deficiency. Because the phenotype of limbal niche cells (NCs) is preserved better in serum-free modified embryonic stem cell ...

The Endoplasmic Reticulum Chaperone Protein GRP94 Is Required for Maintaining Hematopoietic Stem Cell Interactions with the Adult Bone Marrow Niche

Hematopoietic stem cell (HSC) homeostasis in the adult bone marrow (BM) is regulated by both intrinsic gene expression products and interactions with extrinsic factors in the HSC niche. GRP94, an endoplasmic reticulum chaperone, has been reported to be essential for the expression of specific integrins and to selectively regulate early T and B lymphopoiesis. In GRP94 deficient BM chimeras, mult...